Output list
Conference poster
Published 2019
Alzheimer's & Dementia, 15, 7S Pt. 29, P1498 - P1498
The Alzheimer's Association International Conference (AAIC2019) 2019, 14/07/2019–18/07/2019, Los Angeles, CA
Background
Genetic variation in Spondin-1 (SPON1), specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer's disease. The aim of this study was to assess whether the association was present in cognitively normal (CN) older adults.
Methods
Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 CN older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study.
Results
No independent effect of rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between APOE ε4 and rs11023139 in individuals with high Aβ-amyloid burden. APOE ε4/rs11023139-A carriers declined significantly faster than APOE ε4/rs11023139-G_G carriers in measures of global cognition (p=0.011) and verbal episodic memory (p=0.020).
Conclusions
These results suggest that carriage of the SPON1 rs11023139-A allele significantly contributes to a worsening of cognitive performance in APOE ε4 CN older adults with a high neocortical Aβ-amyloid burden.
Conference poster
Published 2018
Alzheimer's & Dementia, 14, 7S Pt. 25, P1368 - P1369
The Alzheimer's Association International Conference (AAIC2018) 2018, 22/07/2018–26/07/2018, Chicago, Illinois
Background
There has been increased interest in the role of dietary patterns and future risk of Alzheimer's disease (AD). However, the specific relationship between protein and fibre intake on cognitive function in older adults at higher risk of AD remains to be determined. This study investigated the association of protein and fibre intake, with cognition using data from the Australian Imaging, Biomarkers and Lifestyle study of ageing (AIBL) cohort.
Methods
Neuropsychological data derived from AIBL (734) were grouped into two cognitive domains (PACC and the Boston non-memory score). Composite scores, calculated by averaging the normalised individual cognitive measure Z scores, were assessed between levels of fibre and protein intake (binary, below/above the recommended daily intake (RDI) age, gender, APOE e4 allele status, total energy intake, education and BMI.
Results
Average values for the AIBL Study Preclinical Alzheimer cognitive (AIBL PACC) score (but not the non-memory) were significantly higher in participants with high protein intake (PACC:0.11 vs PACC:0.68, p=0.046) but not for those with high fibre intake (PACC:0.51 vs PACC:0.53, p>0.05). Adjusted for all confounding variables, this difference was abrogated (p>0.05). Given the level of education as a covariate was strongly related to the PACC score (p<0.0001), we further tested the interaction between education level (<12/12+ years) with low/high protein and fibre intakes. We saw a significant interaction for both protein and fibre groups with education level for the PACC score (education*protein: p=0.014, education*fibre: p=0.051), with those participants with high protein/fibre intakes and 12+ years of education having higher PACC scores as compared to those with <12 years of education and low protein/fibre intakes. Combining both fibre and protein in one three level variable (0=low fibre/low protein, 1=at least 1 fibre/protein high, and 2=both high fibre and protein) identified a significant association with the PACC score (p=0.007), with those participants in the low group and with <12 years of education performing worse for the PACC score as compared with those in the high group with 12+years of education.
Conclusions
This study highlights the importance of adequate protein and fibre intake on cognitive performance in an elderly cognitively normal population.