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Journal article
Stratification of Sepsis Patients on Admission into the Intensive Care Unit According to Differential Plasma Metabolic Phenotypes
Journal of Proteome Research, Vol.23(4), pp.1328-1340
2024
Abstract
Delayed diagnosis of patients with sepsis or septic shock is associated with increased mortality and morbidity. UPLC-MS and NMR spectroscopy were used to measure panels of lipoproteins, lipids, biogenic amines, amino acids, and tryptophan pathway metabolites in blood plasma samples collected from 152 patients within 48 h of admission into the Intensive Care Unit (ICU) where 62 patients had no sepsis, 71 patients had sepsis, and 19 patients had septic shock. Patients with sepsis or septic shock had higher concentrations of neopterin and lower levels of HDL cholesterol and phospholipid particles in comparison to nonsepsis patients. Septic shock could be differentiated from sepsis patients based on different concentrations of 10 lipids, including significantly lower concentrations of five phosphatidylcholine species, three cholesterol esters, one dihydroceramide, and one phosphatidylethanolamine. The Supramolecular Phospholipid Composite (SPC) was reduced in all ICU patients, while the composite markers of acute phase glycoproteins were increased in the sepsis and septic shock patients within 48 h admission into ICU. We show that the plasma metabolic phenotype obtained within 48 h of ICU admission is diagnostic for the presence of sepsis and that septic shock can be differentiated from sepsis based on the lipid profile.
Details
- Title
- Stratification of Sepsis Patients on Admission into the Intensive Care Unit According to Differential Plasma Metabolic Phenotypes
- Authors/Creators
- Sam Lodge - Murdoch University, Centre for Computational and Systems MedicineEdward Litton - Fiona Stanley HospitalNicola Gray Dr - Murdoch University, Centre for Computational and Systems MedicineMonique RyanOscar Millet - CIC bioGUNEMark FearEdward RabyProfessor Andrew Currie - Murdoch University, Centre for Molecular Medicine and Innovative TherapeuticsFiona Wood - Government of Western AustraliaElaine Holmes - Murdoch University, Centre for Computational and Systems MedicineJulien Wist - Murdoch University, Centre for Computational and Systems MedicineJeremy Nicholson - Murdoch University, Health Futures Institute
- Publication Details
- Journal of Proteome Research, Vol.23(4), pp.1328-1340
- Publisher
- American Chemical Society
- Identifiers
- 991005649469107891
- Copyright
- © 2024 The Authors.
- Murdoch Affiliation
- Centre for Computational and Systems Medicine; Health Futures Institute; Australian National Phenome Centre; Centre for Molecular Medicine and Innovative Therapeutics; School of Medical, Molecular and Forensic Sciences
- Language
- English
- Resource Type
- Journal article
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- 2.211 Mass Spectrometry
- 2.211.990 Metabolomics
- Web Of Science research areas
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