Plasmodium: assessment of the antimalarial potential of trifluralin and related compounds using a rat model of malaria, Rattus norvegicus

G.S. Dow; A. Armson; M.R. Boddy; T. Itenge; D. McCarthy; J.E. Parkin; R.C.A. Thompson; J.A. Reynoldson

doi:10.1016/S0014-4894(02)00016-4

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Plasmodium: assessment of the antimalarial potential of trifluralin and related compounds using a rat model of malaria, Rattus norvegicus

Journal article

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Plasmodium: assessment of the antimalarial potential of trifluralin and related compounds using a rat model of malaria, Rattus norvegicus

G.S. Dow, A. Armson, M.R. Boddy, T. Itenge, D. McCarthy, J.E. Parkin, R.C.A. Thompson and J.A. Reynoldson

Experimental Parasitology, Vol.100(3), pp.155-160

2002

DOI: https://doi.org/10.1016/S0014-4894(02)00016-4

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Abstract

A rodent model of malaria, Plasmodium berghei, was used to assess the antimalarial potential of dinitroaniline herbicides. Trifluralin, pendimethalin, oryzalin, and benfluralin were all active against P. berghei in vitro at, or close to, submicromolar concentrations, with a rank order of potency similar to that against other protozoa. The dinitroanilines did not elicit a cytotoxic effect against a mammalian cell line at concentrations 100-fold higher than those for activity against P. berghei. Neither trifluralin nor oryzalin exhibited any antimalarial activity in vivo after oral administration at the maximum dose tolerated by the host. In a pharmacokinetic study, it was found that the lack of in vivo antimalarial activity was due to poor absorption. Other DNs which have better absorption characteristics than either trifluralin or oryzalin may offer more scope for antimalarial activity in vivo.

Details

Title: Plasmodium: assessment of the antimalarial potential of trifluralin and related compounds using a rat model of malaria, Rattus norvegicus
Authors/Creators: G.S. Dow (Author/Creator) - Murdoch University
A. Armson (Author/Creator) - Murdoch University
M.R. Boddy (Author/Creator) - Curtin University
T. Itenge (Author/Creator) - Murdoch University
D. McCarthy (Author/Creator) - Murdoch University
J.E. Parkin (Author/Creator) - Curtin University
R.C.A. Thompson (Author/Creator) - Murdoch University
J.A. Reynoldson (Author/Creator) - Murdoch University
Publication Details: Experimental Parasitology, Vol.100(3), pp.155-160
Publisher: Academic Press
Identifiers: 991005540041707891
Copyright: © 2002 Elsevier Science (USA)
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.217 Parasitology - Malaria, Toxoplasmosis & Coccidiosis; 1.217.59 Malaria
Web Of Science research areas: Parasitology
ESI research areas: Microbiology