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Journal article
Maternal dietary intervention during lactation impacts the maternal faecal and human milk microbiota
Journal of applied microbiology, Vol.135(5), lxae024
2024
PMID: 38323424
Abstract
To determine the effect of a two-week reduced fat and sugar and increased fibre maternal dietary intervention on the maternal faecal and human milk (HM) microbiomes.
Faecal swabs and HM samples were collected from mothers (n = 11) immediately pre-intervention, immediately post-intervention, and 4- and 8-weeks post-intervention, and were analysed using full-length 16S rRNA gene sequencing. Maternal macronutrient intake was assessed at baseline and during the intervention. Maternal fat and sugar intake during the intervention were significantly lower than pre-intervention (P=<0.001, 0.005, respectively). Significant changes in the bacterial composition of maternal faeces were detected after the dietary intervention, with decreases in the relative abundance of Bacteroides caccae (P=<0.001) and increases in the relative abundance of Faecalibacillus intestinalis (P = 0.006). In HM, the diet resulted in a significant increase in Cutibacterium acnes (P = 0.001) and a decrease in Haemophilus parainfluenzae (P=<0.001). The effect of the diet continued after the intervention, with faecal swabs and HM samples taken 4- and 8-weeks after the diet showing significant differences compared to baseline.
This pilot study demonstrates that short-term changes in maternal diet during lactation can alter the bacterial composition of the maternal faeces and HM. Clinical trial registration: Australian New Zealand Clinical Trials Registry (ACTRN12619000606189). Website: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377188&isReview=true.
Details
- Title
- Maternal dietary intervention during lactation impacts the maternal faecal and human milk microbiota
- Authors/Creators
- Azhar S Sindi - The University of Western AustraliaLisa F Stinson - Community Arts NetworkZoya Gridneva - The University of Western AustraliaGabriela E Leghi - The University of AdelaideMerryn J Netting - South Australian Health and Medical Research InstituteMary E Wlodek - The University of Western AustraliaBeverly S Muhlhausler - The University of AdelaideAlethea Rea - Murdoch University, Centre for Terrestrial Ecosystem Science and SustainabilityMichelle L Trevenen - The University of Western AustraliaDonna T Geddes - The University of Western AustraliaMatthew S Payne - The University of Western Australia
- Publication Details
- Journal of applied microbiology, Vol.135(5), lxae024
- Publisher
- Oxford University Press on behalf of Applied Microbiology International.
- Identifiers
- 991005656369907891
- Copyright
- © The Author(s) 2024.
- Murdoch Affiliation
- School of Mathematics, Statistics, Chemistry and Physics
- Language
- English
- Resource Type
- Journal article
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