Effect on humoral tolerance (IgG and IgE) in dogs by oral administration of ovalbumin and Der p I

P. Deplazes; W.J. Penhale; W.K. Greene; R.C.A. Thompson

doi:10.1016/0165-2427(94)05346-T

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Effect on humoral tolerance (IgG and IgE) in dogs by oral administration of ovalbumin and Der p I

Journal article

Peer reviewed

Effect on humoral tolerance (IgG and IgE) in dogs by oral administration of ovalbumin and Der p I

P. Deplazes, W.J. Penhale, W.K. Greene and R.C.A. Thompson

Veterinary Immunology and Immunopathology, Vol.45(3-4), pp.361-367

1995

DOI: https://doi.org/10.1016/0165-2427(94)05346-T

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Abstract

The effect of oral administration of ovalbumin (OVA) or recombinant house dust mite allergen (Der p I) to dogs upon specific IgG and IgE reactions to subcutaneous immunization with these antigens was studied. Daily feeding of 10 x 10 g of OVA resulted in a non-responsiveness to subsequent parenteral immunization with OVA in two young dogs. The same two dogs were also immunized parenterally with Der p I and showed a pronounced IgG response against native Der p I, confirming that the non-responsiveness to OVA was antigen-specific. Thus, it has been demonstrated that it is possible to induce oral tolerance in dogs. Two other dogs of the same litter that received 2 x 10 mg of recombinant Der p I in a crude yeast lysate per os reacted to immunization with OVA with pronounced IgG and IgE production against OVA, further confirming the antigen-specificity of the OVA tolerance. However, tolerance to Der p I was not induced, as evidenced by a strong IgG response to immunization after per os application of the antigen, possibly because the oral dose was too small.

Details

Title: Effect on humoral tolerance (IgG and IgE) in dogs by oral administration of ovalbumin and Der p I
Authors/Creators: P. Deplazes (Author/Creator) - Murdoch University
W.J. Penhale (Author/Creator) - Murdoch University
W.K. Greene (Author/Creator) - Murdoch University
R.C.A. Thompson (Author/Creator) - Murdoch University
Publication Details: Veterinary Immunology and Immunopathology, Vol.45(3-4), pp.361-367
Publisher: Elsevier BV
Identifiers: 991005544210607891
Copyright: © 1995 Elsevier B.V.
Murdoch Affiliation: School of Veterinary Studies
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.65 Allergy; 1.65.264 Allergy Mechanisms
Web Of Science research areas: Immunology; Veterinary Sciences
ESI research areas: Plant & Animal Science