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Published (Version of Record)CC BY-NC-ND V4.0, Open Access
Journal article
Defining sepsis in small animals
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000), Vol.34(2), pp.97-109
2024
PMID: 38351524
Abstract
Objective
To discuss the definitions of sepsis in human and veterinary medicine.
Design
International, multicenter position statement on the need for consensus definitions of sepsis in veterinary medicine.
Setting
Veterinary private practice and university teaching hospitals.
Animals
Dogs and cats.
Interventions
None.
Measurements and Main Results
Sepsis is a life-threatening condition associated with the body's response to an infection. In human medicine, sepsis has been defined by consensus on 3 occasions, most recently in 2016. In veterinary medicine, there is little uniformity in how sepsis is defined and no consensus on how to identify it clinically. Most publications rely on modified criteria derived from the 1991 and 2001 human consensus definitions. There is a divergence between the human and veterinary descriptions of sepsis and no consensus on how to diagnose the syndrome. This impedes research, hampers the translation of pathophysiology insights to the clinic, and limits our abilities to optimize patient care. It may be time to formally define sepsis in veterinary medicine to help the field move forward. In this narrative review, we present a synopsis of prior attempts to define sepsis in human and veterinary medicine, discuss developments in our understanding, and highlight some criticisms and shortcomings of existing schemes.
Conclusions
This review is intended to serve as the foundation of current efforts to establish a consensus definition for sepsis in small animals and ultimately generate evidence-based criteria for its recognition in veterinary clinical practice.
Details
- Title
- Defining sepsis in small animals
- Authors/Creators
- Stefano Cortellini - Royal Veterinary CollegeAmy E DeClue - EMERGENCYMassimo Giunti - University of BolognaRobert Goggs - New York State College of Veterinary MedicineKate Hopper - University of California, DavisJulie M Menard - University of CalgaryRodrigo C Rabelo - Intensivet Veterinary Consulting, Brasília, BrazilElizabeth A Rozanski - Tufts UniversityClaire R Sharp - School of Veterinary Medicine, Murdoch University, Perth, Western Australia, AustraliaDeborah C Silverstein - University of PennsylvaniaVirginia Sinnott-Stutzman - BluePearl, Tampa, Florida, USAGiacomo Stanzani - Dick White Referrals, Six Mile Bottom, UK
- Publication Details
- Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000), Vol.34(2), pp.97-109
- Publisher
- Wiley Periodicals LLC on behalf of Veterinary Emergency and Critical Care Society.
- Grant note
- American College of Veterinary Emergency and Critical Care
- Identifiers
- 991005638868607891
- Copyright
- © 2024 The Authors.
- Murdoch Affiliation
- School of Veterinary Medicine; Centre for Terrestrial Ecosystem Science and Sustainability
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.154 Assisted Ventilation
- 1.154.360 Procalcitonin
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science