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CC BY-NC V4.0, Open Access
Journal article
CD3+ T-cell: CD14+ monocyte complexes are dynamic and increased with HIV and glucose intolerance
The Journal of immunology (1950), Vol.214(3), pp.516-531
2025
PMID: 40073149
Abstract
Persistent systemic inflammation is associated with an elevated risk of cardiometabolic diseases. However, the characteristics of the innate and adaptive immune systems in individuals who develop these conditions remain poorly defined. Doublets, or cell-cell complexes, are routinely eliminated from flow cytometric and other immune phenotyping analyses, which limits our understanding of their relationship to disease states. Using well-characterized clinical cohorts, including participants with controlled human immunodeficiency virus (HIV) as a model for chronic inflammation and increased immune cell interactions, we show that circulating CD14+ monocytes complexed to CD3+ T cells are dynamic, biologically relevant, and increased in individuals with diabetes after adjusting for confounding factors. The complexes form functional immune synapses with increased expression of proinflammatory cytokines and greater glucose utilization. Furthermore, in persons with HIV, the CD3+ T cell: CD14+ monocyte complexes had more HIV copies compared to matched CD14+ monocytes or CD4+ T cells alone. Our results demonstrate that circulating CD3+ T-cell: CD14+ monocyte pairs represent dynamic cellular interactions that may contribute to inflammation and cardiometabolic disease pathogenesis. CD3+ T-cell: CD14+ monocyte complexes may originate or be maintained, in part, by chronic viral infections. These findings provide a foundation for future studies investigating mechanisms linking T cell-monocyte cell-cell complexes to developing immune-mediated diseases, including HIV and diabetes.
Details
- Title
- CD3+ T-cell: CD14+ monocyte complexes are dynamic and increased with HIV and glucose intolerance
- Authors/Creators
- Laventa M Obare - Vanderbilt University Medical CenterJoshua Simmons - Vanderbilt University Medical CenterJared Oakes - Vanderbilt University Medical CenterXiuqi Zhang - Vanderbilt University Medical CenterCindy Nochowicz - Vanderbilt University Medical CenterStephen Priest - Vanderbilt University Medical CenterSamuel S Bailin - Vanderbilt University Medical CenterChristian M Warren - VA Tennessee Valley Healthcare SystemMona Mashayekhi - Vanderbilt University Medical CenterHeather K Beasley - Vanderbilt UniversityJianqiang Shao - University of IowaLeslie M Meenderink - Vanderbilt University Medical CenterQuanhu Sheng - Vanderbilt UniversityJoey Stolze - Vanderbilt UniversityRama Gangula - Vanderbilt University Medical CenterTarek Absi - Vanderbilt University Medical CenterYan Ru Su - Vanderbilt University Medical CenterKit Neikirk - Vanderbilt UniversityAbha Chopra - Murdoch UniversityCurtis L Gabriel - Vanderbilt University Medical CenterTecla Temu - University of WashingtonSuman Pakala - Vanderbilt University Medical CenterErin M Wilfong - Vanderbilt University Medical CenterSara Gianella - University of California San DiegoElizabeth J Phillips - Vanderbilt University Medical CenterDavid G Harrison - Vanderbilt University Medical CenterAntentor Hinton - Vanderbilt UniversitySpyros A Kalams - Vanderbilt University Medical CenterAnnet Kirabo - Vanderbilt UniversitySimon A Mallal - Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, United StatesJohn R Koethe - Vanderbilt University Medical CenterCelestine N Wanjalla - Vanderbilt University Medical Center
- Publication Details
- The Journal of immunology (1950), Vol.214(3), pp.516-531
- Publisher
- Oxford University Press on behalf of The American Association of Immunologists.; OXFORD
- Number of pages
- 16
- Grant note
- 1021480 / Burroughs Wellcome
- Identifiers
- 991005753830507891
- Copyright
- © The Author(s) 2025.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases; Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.1372 HIV Comorbidities
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology