Files and links (1)
CC BY V4.0, Open Access
Journal article
Beta tACS of varying intensities differentially affect resting-state and movement-related M1-M1 connectivity
Frontiers in neuroscience, Vol.18, 1425527
2024
Abstract
Due to the interconnected nature of the brain, changes in one region are likely to affect other structurally and functionally connected regions. Emerging evidence indicates that single-site transcranial alternating current stimulation (tACS) can modulate functional connectivity between stimulated and interconnected unstimulated brain regions. However, our understanding of the network response to tACS is incomplete. Here, we investigated the effect of beta tACS of different intensities on phase-based connectivity between the left and right primary motor cortices in 21 healthy young adults (13 female; mean age 24.30 ± 4.84 years). Participants underwent four sessions of 20 min of 20 Hz tACS of varying intensities (sham, 0.5 mA, 1.0 mA, or 1.5 mA) applied to the left primary motor cortex at rest. We recorded resting-state and event-related electroencephalography (EEG) before and after tACS, analyzing changes in sensorimotor beta (13–30 Hz) imaginary coherence (ImCoh), an index of functional connectivity. Event-related EEG captured movement-related beta activity as participants performed self-paced button presses using their right index finger. For resting-state connectivity, we observed intensity-dependent changes in beta ImCoh: sham and 0.5 mA stimulation resulted in an increase in beta ImCoh, while 1.0 mA and 1.5 mA stimulation decreased beta ImCoh. For event-related connectivity, 1.5 mA stimulation decreased broadband ImCoh (4–90 Hz) during movement execution. None of the other stimulation intensities significantly modulated event-related ImCoh during movement preparation, execution, or termination. Interestingly, changes in ImCoh during movement preparation following 1.0 mA and 1.5 mA stimulation were significantly associated with participants’ pre-tACS peak beta frequency, suggesting that the alignment of stimulation frequency and peak beta frequency affected the extent of neuromodulation. Collectively, these results suggest that beta tACS applied to a single site influences connectivity within the motor network in a manner that depends on the intensity and frequency of stimulation. These findings have significant implications for both research and clinical applications.
Details
- Title
- Beta tACS of varying intensities differentially affect resting-state and movement-related M1-M1 connectivity
- Authors/Creators
- Kym WansbroughWelber MarinovicHakuei FujiyamaAnn-Maree Vallence
- Publication Details
- Frontiers in neuroscience, Vol.18, 1425527
- Publisher
- Frontiers Media S.A.
- Number of pages
- 18
- Grant note
- Australian Research Council Discovery Early Career Researcher Award: DE190100694
The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. AMV was supported by Australian Research Council Discovery Early Career Researcher Award (DE190100694). KW was supported by the Australian Government Research Training Program scholarship.
- Identifiers
- 991005706365707891
- Copyright
- © 2024 Wansbrough et al.
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
9 File views/ downloads
43 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior