Conference presentation
Hybridization based enrichment for genotyping HLA and KIR genes using Next Generation Sequencing
Science on the Swan (Perth, Western Australia, 21/04/2015–23/04/2015)
2015
Abstract
Several disease association studies indicate that, the interactions between the KIR and HLA loci may have a role in infectious diseases, autoimmune disorders, cancer and reproduction. Current typing methods for HLA Loci use PCR for whole gene amplification or selected exon amplification. The Killer cell immunoglobulin-like receptors (KIR) genes are polymorphic and the gene complex is polygenic with a varying number of inhibitory (iKIRs) and activating (aKIRs) receptors. Due to this complexity of the KIR locus, genotyping is not performed as routinely.
Details
- Title
- Hybridization based enrichment for genotyping HLA and KIR genes using Next Generation Sequencing
- Authors/Creators
- D. Cooper (Author/Creator)A. Chopra (Author/Creator)J. Blinco (Author/Creator)S. Leary (Author/Creator)M. Watson (Author/Creator)S. Mallal (Author/Creator)
- Conference
- Science on the Swan (Perth, Western Australia, 21/04/2015–23/04/2015)
- Identifiers
- 991005544629107891
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Conference presentation
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