The development of a Metabonomic‐Based drug safety testing paradigm

Muireann Coen; Elaine Holmes; Jeremy K. Nicholson; John C. Lindon

doi:10.1002/9780470699638.ch18

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Book chapter

The development of a Metabonomic‐Based drug safety testing paradigm

Muireann Coen, Elaine Holmes, Jeremy K. Nicholson and John C. Lindon

Toxicogenomics: A Powerful Tool for Toxicity Assessment, pp.309-343

John Wiley & Sons, Ltd

2008

DOI: https://doi.org/10.1002/9780470699638.ch18

Abstract

Consortium on Metabonomic Toxicology (COMET) projects

COnsortium on MEtabonomic Toxicology (COMET‐2)

metabonomic expert system

metabonomics and NMR and HPLC–MS

metabonomic‐based drug safety testing paradigm

multivariate statistical batch processing and NMR spectral data

O‐PLS‐DA modeling and ‘binned’ UPLC–MS data

pharmacometabonomics ‐ pre‐dose metabolite profile response prediction

This chapter contains sections titled: Introduction Analytical Platforms Utilized for Metabonomics Statistical Tools Applied to Model Metabonomic Data Integrated Metabonomic and ‘Multi‐omic’ Studies COMET: A Consortium Project Using NMR‐driven Metabonomics The COMET‐2 Project Prospects for the Future Concluding Remarks References

Details

Title: The development of a Metabonomic‐Based drug safety testing paradigm
Authors/Creators: Muireann Coen - Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
Elaine Holmes - Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
Jeremy K. Nicholson - Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
John C. Lindon - Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, UK
Contributors: Saura C. Sahu (Editor)
Publication Details: Toxicogenomics: A Powerful Tool for Toxicity Assessment, pp.309-343
Publisher: John Wiley & Sons, Ltd; Chichester, UK
Identifiers: 991005598968107891
Murdoch Affiliation: Health Futures Institute; Centre for Computational and Systems Medicine
Language: English
Resource Type: Book chapter

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